Herbal Medicine from Single Clove Garlic Oil Extract Ameliorates Hepatic Steatosis and Oxidative Status in High Fat Diet Mice
- Author:
Siti Nur Arifah
;
Mochammad Fitri Atho’illah
;
Betty Lukiati
;
Sri Rahayu Lestar
- Publication Type:Journal Article
- Keywords:
single clove garlic oil;
superoxide dismutase;
tumour necrosis factor-α;
hepaticsteatosis;
high fat diet
- From:Malaysian Journal of Medical Sciences
2020;27(1):46-56
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: High fat diet (HFD) can cause lipid accumulation and contribute to various
metabolic disorders. Single clove garlic oil (SCGO) has advantages over regular garlic due to its
higher amounts of organosulfide compounds in particular. This study aimed to determine the
ability of SCGO extract to ameliorate hepatic steatosis and improve oxidative status by modulating
expression of tumour necrosis factor α and superoxide dismutase in mice fed a HFD.
Methods: Twenty-four adult male Balb/C mice were divided into six groups: i) normal diet;
ii) positive control diet; iii) negative control diet; and iv) HFD with SCGO at 12.5 mg/kg body weight
(mg/kg BW); v) HFD with SCGO at 25 mg/kg BW, vi) HFD with SCGO at 50 mg/kg BW. Liver weight
and morphology, spleen weight, serum levels of superoxide dismutase (SOD) and tumour necrosis
factor α (TNF-α), TNF-α expression in the aorta and lipid profiles were assessed at the end of the
experimental period.
Results: SCGO treatment was associated with significant decreases in liver and spleen
weight as well as amelioration of hepatic steatosis. SCGO treatment also decreased TNF-α levels
and expression. Serum levels of SOD in the SCGO groups were significantly increased compared
with the negative control group. Lipid profiles were improved in the SCGO treatment groups
compared with the negative control group.
Conclusion: SCGO as an herbal medicine could be an effective treatment for degenerative
disorders caused by HFD.
- Full text:3.2020my0838.pdf
