Antinociceptive Effect of Intraperitoneally Administered 5,5-dimethyl-1-pyrroline N-oxide on Formalin Induced Nociception in Rats.
10.4097/kjae.2008.54.3.S35
- Author:
Woo suk CHUNG
1
;
Young gwon GO
;
Won hyung LEE
Author Information
1. Department of Anesthesiology and Pain Medicine, Research Institute for Medicial Sciences,Chungnam National University College of Medicine, Daejeon, Korea. whlee@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
DMPO;
formalin test;
ROS
- MeSH:
Animals;
Central Nervous System Sensitization;
Formaldehyde;
Injections, Intraperitoneal;
Nociception;
Pain Measurement;
Rats;
Reactive Oxygen Species
- From:Korean Journal of Anesthesiology
2008;54(3):S35-S39
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Reactive oxygen species (ROS) is known to be involved in chronic and persistent pain.By using the ROS scavenger 5,5-dimethyl-1-pyrroline N-oxide (DMPO), we studied the effects of ROS on formalin-induced nociception in rats. METHODS: 5% formalin was injected in the left hind paw after intraperitoneal injection of saline or various doses of DMPO (10 mg/kg, 30 mg/kg, 100 mg/kg).Number of flinches was measured in a 5 minute interval for 1 hour. RESULTS: Formalin injected into the left hind paw induced a biphasic nociceptive behaviour. Intraperitoneal injection of DMPO diminished nociceptive behaviors dose-dependently during phase 2 but not phase 1. CONCLUSIONS: ROS might be involved in central sensitization and DMPO, a ROS scavenger, posses antinociceptive property in rats subjected to formalin induced hyperalgesia.
