Primary extragonadal vaginal yolk sac tumour: A case report
- Author:
Wong Yin Ping
1
Author Information
1. Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia.
- Collective Name:Azyani Yahaya; Roziasyazni Che Abdul Aziz; Pik Yuen Chia; C-Khai Loh; Geok Chin Tan
- Publication Type:Case Reports
- Keywords:
CD117;
children;
extragonadal;
immunohistochemistry;
yolk sac tumour
- From:The Malaysian Journal of Pathology
2020;42(2):301-305
- CountryMalaysia
- Language:English
-
Abstract:
Yolk sac tumour (YST) or endodermal sinus tumour is rare and typically seen in gonads.
Case Report: We described a case of extragonadal vaginal YST in a one year and seven months old
girl who presented with vaginal discharge and bleeding, and discuss its differential diagnosis and
potential pitfalls in immunohistochemistry. She was found to have a suprapubic mass on examination.
The serum alpha fetoprotein was 11919.4 ng/mL. Computed tomography of the pelvis revealed a large
6.4 cm heterogenous pelvic mass. Colposcopic examination of the pelvis showed a fungating vaginal
mass that was subsequently confirmed as a yolk sac tumour. Immunohistochemically, the malignant
cells were positive toward CKAE1/AE3, AFP and glypican-3, as well as CD117. Discussion: Solid
pattern extragonadal vaginal YST may morphologically resemble dysgerminoma that is also CD117
positive, while the glandular pattern YST may have clear cytoplasm and is positive for cytokeratin;
hence, may resemble clear cell carcinoma. Being mindful of these potential diagnostic caveats is
necessary to prevent misdiagnosis.
- Full text:5.2020my01077.pdf
