The role of macrophage polarization in parasitic infections: a review

VernacularTitle:巨噬细胞极化在寄生虫感染中的作用研究进展
Author: Juan CAI ^{1
,

2} ; Lin HUANG ^{1
,

2
,

3} ; Ling-Jun WANG ^{1
,

2} ; Ming-Hui ZHENG ^{1
,

2} ; Hui LIU ^{1
,

2}
Author Information

1. Department of Parasitology, Zunyi Medical College, Zunyi 563000, China
2. Guizhou Key Laboratory of Gene Detection and Treatment, Zunyi Medical College, China
3. Qiannan Medical College for Nationalities, China
Publication Type:Journal Article
Keywords: Macrophage polarization; Parasite; Immune response
From: Chinese Journal of Schistosomiasis Control 2020;32(4):432-435
CountryChina
Language:Chinese
Abstract: Macrophages are important members of innate immunity and play an extremely important role in the host defense against pathogenic infections, tumors, and allergic diseases. Macrophages have a high degree of plasticity, and may be polarized into classical activated macrophages (M1 macrophages) and alternative activated macrophages (M2 macrophages) under the stimulation of different environments. M1 macrophages are found to promote inflammatory responses, which facilitates the clearance of pathogens, while M2 macrophages may inhibit inflammatory responses, which facilitates the survival and reproduction of pathogens. This review summarizes the role of macrophage polarization in parasitic infections, so as to provide insights into the prevention and treatment of parasitic diseases.