A pair of enantiomeric sesquiterpenoids with neuroprotective effects from Chloranthus henryi
10.16438/j.0513-4870.2020-0491
- VernacularTitle:宽叶金粟兰中1对具有神经保护活性的倍半萜对映体
- Author:
Fang-you CHEN
1
;
Hong-tao LI
1
;
Jie CHEN
1
;
Peng-cheng SHUANG
1
;
Yong-ming LUO
1
Author Information
1. School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
- Publication Type:Research Article
- Keywords:
italic>Chloranthus henryi;
sesquiterpene enantiomers;
neuroprotective effects
- From:
Acta Pharmaceutica Sinica
2020;55(8):1855-1858
- CountryChina
- Language:Chinese
-
Abstract:
An ethanol extract of Chloranthus henryi (Chloranthaceae) was subjected to various chromatographic procedures including silica gel column chromatography, MCI column chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Five purified sesquiterpenes analyzed by spectroscopic analyses (MS, IR, NMR) and single crystal X-ray diffraction were elucidated as (1S,6S,8R)-8-ethoxychlomultin C (1a), (1R,6R,8S)-8-ethoxychlomultin C (1b), (+)-phaeocaulin D (2), atractylenolide Ⅰ (3), and 8-β-ethoxyasterolid (4). Compounds 1a and 1b were a new pair of sesquiterpene enantiomers and compounds 2-4 were isolated from this plant for the first time. Compounds 1a, 1b, 2 and 3 increased cell viability in H2O2-treated PC12 cells from (43.41 ± 1.59) % to (61.71 ± 7.56) %, (66.05 ± 5.61) %, (74.34 ± 3.32) % and (69.58 ± 5.02) % at 10 μmol·L-1, respectively.
