Ideas and strategies for investigating the bioactive constituents of animal derived traditional Chinese medicines based on integrated "proteomics/peptidomics-modifications" methods
10.16438/j.0513-4870.2019-1035
- VernacularTitle:基于“蛋白质/肽组学-修饰组学”研究动物药功效物质基础的思路与方法
- Author:
Rui LIU
1
,
2
,
3
;
Ming ZHAO
1
,
3
;
Jin-ao DUAN
1
,
3
Author Information
1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China
2. Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics, Nanjing University of Chinese Medicine, Nanjing 210023, China
3. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
horn;
gelatin;
animal derived traditional Chinese medicine;
proteomes;
peptidomes;
modification
- From:
Acta Pharmaceutica Sinica
2020;55(8):1735-1743
- CountryChina
- Language:Chinese
-
Abstract:
Animal derived traditional Chinese medicines (ATCMs) are an important part of traditional Chinese medicine (TCM). The lack of proper ideas and strategies made it not systematic and perfect enough on investigating bioactive components and quality evaluation of ATCMs, which restrict many aspects of ATCMs investigation including clinical applications, pharmaceutical technologies, and quality control. Therefore, based on our previous investigations of animal horn and animal derived gelatin TCMs, and the research progress at home and abroad, ideas and strategies for investigating the correlations between proteins/peptides and their bioactivities in animal horn and animal gelatin derived TCMs based on integrated "proteomics/peptidomics-modifications" methods was proposed. Firstly, proteomics and peptidomics analysis can be used to study proteins and peptides in ATCMs. Secondly, modification analysis can be used to reveal those chemical modifications on proteins and peptides of ATCMs. Thirdly, the correlations between components, modifications and traditional bioactivities can be systemic discussed. Based on the present study, hopefully, enough evidences and reference can be provided to resolve the issues in ATCMs investigations on modernization and bioactive material basis.
