Research progress of photothermal therapy combined with chemotherapy based on nano co-delivery strategy
10.16438/j.0513-4870.2019-0993
- VernacularTitle:基于纳米共载策略的光热治疗联合化疗抗肿瘤研究进展
- Author:
Hai-ting XU
1
;
Yi-han WU
1
;
Jin-feng SHI
1
;
Jia-xin LI
1
;
Jin-ming ZHANG
1
;
Chao-mei FU
1
Author Information
1. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
- Publication Type:Research Article
- Keywords:
photothermal therapy;
nanocarrier;
chemotherapy drug;
co-delivery;
tumor therapy
- From:
Acta Pharmaceutica Sinica
2020;55(8):1774-1783
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, multi-modal combined anti-tumor has become an effective strategy for clinical tumor treatment. Photothermal therapy with its characteristics of minimally invasive, controllable, high efficiency, and strong specificity, can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment. The research shows that the combination of photothermal therapy and chemotherapy has better synergistic antitumor effect. However, chemotherapeutic drugs and photothermal agents may have different pharmacokinetic behaviors in vivo, so it is difficult to ensure their effective transmission in tumor site, and the free form is easy to be metabolized and degraded in vivo. How to deliver the two therapeutic modes of drugs / photothermal reagents to tumor tissues in a specific, efficient and synchronous manner to achieve the best combined antitumor effect is an important problem to be solved in the combined antitumor application. The development of nano-drug delivery technology provides a new idea for the application of tumor treatment. In this paper, combined with the latest research progress in this field, the anti-tumor mechanism of photothermal therapy combined with chemotherapy, the advantages of nano drug delivery, the types and characteristics of commonly used nano materials and the principle of drug delivery are reviewed in order to provide a reference for the further development of multi-mode combined treatment of tumor.
