Progress in technology of long-acting preparations of protein and peptide drugs
10.11665/j.issn.1000-5048.20200407
- VernacularTitle:蛋白及多肽类药物长效化制剂学技术研究进展
- Author:
Yuan DING
1
;
Xin CHEN
;
Jiasheng TU
;
Chunmeng SUN
Author Information
1. 中国药科大学药用辅料及仿创药物研发评价中心
- Publication Type:Journal Article
- Keywords:
protein and peptide drugs;
long-acting performance;
extended-release and controlled-release;
formulation improvement;
advances
- From:
Journal of China Pharmaceutical University
2020;51(4):433-440
- CountryChina
- Language:Chinese
-
Abstract:
As one of the most important biological drugs, protein and peptide drugs have been increasingly used in the prevention, diagnosis and treatment of diseases in recent years. However, most of them need to be injected and lack of long-acting formulations, which brings many troubles to patients suffering from chronic diseases. In this review, we summarized the strategies for engineering long-acting formulations for proteins and peptides via preparation means, including extended-release injection, implant, oral preparations and transdermal drug delivery systems, and analyzed their release mechanisms, research advances, advantages and shortcomings, thereby providing potential approaches for promoting the formulation improvement of these drugs.
