Trichosporon asahii fungaemia in an immunocompetent polytrauma patient who received multiple antibiotics
- Author:
Chuan Hun Ding
1
Author Information
1. Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
- Collective Name:Tzar Mohd Nizam Khaithir; Asrul Abdul Wahab; Mohd Ali Faiz; Wan Rosli Saarah
- Publication Type:Case Reports
- Keywords:
Trichosporon asahii;
polytrauma;
ID 32 C;
voriconazole
- From:The Malaysian Journal of Pathology
2020;42(2):293-296
- CountryMalaysia
- Language:English
-
Abstract:
Trichosporon asahii is a yeast-like fungus that is emerging as an important cause of invasive infections
in tertiary medical centres. A 58-year-old Chinese man with no known medical illnesses presented
with liver lacerations and multiple fractures following an alleged 12-foot fall at a construction
site. The gravity of his injuries and poor haemodynamic status necessitated an intensive care unit
(ICU) admission, during which several febrile episodes were detected and multiple antibiotics were
administered. After being in the ICU for at least two weeks, a urease-positive yeast was isolated from
the patient’s blood. The yeast formed dry, fuzzy and wrinkled white colonies on Sabouraud dextrose
agar following prolonged incubation, and produced blastoconidia, true hyphae, pseudohyphae and
arthroconidia on slide culture. It was identified biochemically by the ID 32 C kit as T. asahii. The
yeast had elevated minimal inhibitory concentration (MIC) values to fluconazole, amphotericin B,
flucytosine and all echinocandins tested. In view of this, the patient was treated with voriconazole
and was successfully transferred to the general medical ward.
- Full text:5.2020my01075.pdf
