Merkel cell carcinoma: Preparing to go the distance
- Author:
Arumugam Mohan
1
Author Information
1. Department Of Internal Medicine Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
- Collective Name:Adawiyah Jamil; Rayhan Aghani Amiseno; Nurwahyuna Rosli; Nordashima Abdul Shukor
- Publication Type:Case Reports
- Keywords:
Merkel cell carcinoma;
neuroendocrine tumour;
Polyomavirus
- From:The Malaysian Journal of Pathology
2020;42(2):277-281
- CountryMalaysia
- Language:English
-
Abstract:
Merkel cell carcinoma (MCC) is a rare and aggressive malignancy of the skin,
with poor clinical outcomes. Typical conditions include a rapidly growing, solitary dome-shaped,
violaceous nodule. Several root causes have been identified - sun exposure, age, lighter skin,
immunocompromised state, and polyomavirus infection. Wide local excision is the best treatment.
The tumour is radiotherapy-responsive. However, the success rate of the treatment with chemotherapy
is rather limited. Immunotherapy has shown promising results. Early detection is important to
prevent morbidity and mortality. Case Report: In this literature work, we reported on a particular
case of MCC, as exhibited by an 84-year-old Chinese woman, and discussed the clinical features and
management of MCC. Discussion: We highlighted that MCC cases have a link to the polyomavirus
5. Patients who were identified with the Polyomavirus 5, and underwent immunotherapy, were seen
to depict much better prognosis.
- Full text:5.2020my01072.pdf
