Wilms tumour with poor response to pre-operative chemotherapy: A report of 2 cases
- Author:
Tan Henry Chor Lip
1
Author Information
1. Department of General Surgery, Faculty of Medicine, National University of Malaysia Medical Centre, Kuala Lumpur
- Collective Name:Jih Huei Tan; V Muthualhagi Vellusamy; Yabitha Vasavan; Chun Sen Lim
- Publication Type:Other Types
- Keywords:
Child;
Wilms tumour;
kidney neoplasm
- From:The Malaysian Journal of Pathology
2020;42(2):267-271
- CountryMalaysia
- Language:English
-
Abstract:
Majority of Wilms tumour (WT) responds well to pre-operative chemotherapy. In
Malaysia, incidence of WT is rare with only two cases reported per one million populations yearly.
This case report is to highlight on the awareness of WT in an Asian population and highlight two
cases and challenges faced after pre-operative chemotherapy. Case Report: In this case series, we
report on two cases of WT which had poor response to pre-operative chemotherapy. Both cases
underwent surgery after pre-operative chemotherapy and recovery was uneventful during a two-year
follow-up. Discussion: Both patients had chemotherapy prior planned surgery, but had unfortunate
poor tumour response. The tumour progressed in size which required a radical nephrectomy. The
histology report for the first case had more than 60% blastemal cells remaining despite giving
pre-operative chemotherapy with no focal anaplasia. This showed poor response to chemotherapy
evidenced by the high number of blastemal cells. The second case was a stromal type WT which
is known for poor response and may lead to enhancement of growth and maturation induced by
chemotherapy. These were the possible reason of poor response of WT in these two cases.
- Full text:5.2020my01070.pdf
