CIP2A expression in high grade prostatic intraepithelial neoplasia and prostate adenocarcinoma: a tissue microarray study
- Author:
Celĺkden Sevda Gerek
1
Author Information
1. Suleyman Demirel University School of Medicine, Department of Pathology, Isparta, Turkey
- Collective Name:Sirin Baspĺnar; Sefa Alperen Ozturk; Adnan Karaĺbrahĺmoglu
- Publication Type:Journal Article
- Keywords:
CIP2A;
prostate cancer;
high grade prostatic intraepithelial neoplasia
- From:The Malaysian Journal of Pathology
2020;42(2):227-236
- CountryMalaysia
- Language:English
-
Abstract:
CIP2A is an oncoprotein involved in the progression of several human malignancies.
It has recently been described as a prognostic marker in many cancers. The present study aimed to
investigate the immunohistochemical expression of CIP2A in benign prostatic hyperplasia (BPH),
high grade prostatic intraepithelial neoplasia (HGPIN) and prostate cancer (PC), and to analyse the
association with the clinicopathological parameters in PC cases to define its role in the development and
progression of PC. Materials and Methods: Immunohistochemical staining for CIP2A was performed
on the tissue microarray sections of 105 PC, 27 HGPIN and 27 BPH tissues. The CIP2A expression
scores were compared with several clinicopathological parameters. Results: CIP2A was expressed
in 96,2% of PC, 55,6% of HGPIN and 40,7% of BPH tissues. The expression of CIP2A in PC was
significantly higher than in HGPIN (p<0.0001) and BPH (p<0.0001) cases. CIP2A expression score
was significantly associated with Gleason score (p=0.032) and lymphovascular invasion (p=0.039).
Nevertheless, there was no statistically significant association between the expression of CIP2A and
perineural invasion, pT stage, metastasis and recurrence (p>0.05). Multivariate analysis indicated
that GS, lymphovascular invasion, distant metastasis were independent prognostic factors for PC
patients but, CIP2A expression score was not found to be a prognostic factor. Additionally, there
was no significant difference between the survival times of patients according to CIP2A expression
(p=0.174). Conclusion: According to our results, the expression of CIP2A protein is increased in
PC and its expression may be involved in the development, differentiation, and aggressiveness of
PC. However, further studies are needed to confirm our findings and to clarify the role of CIP2A
in the development of PC.
- Full text:5.2020my01065.pdf
