A pilot study on pattern B lipoprotein profile in Malaysia
- Author:
Thambiah Subashini C.
1
Author Information
1. Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor Darul Ehsan, Malaysia
- Collective Name:Noor Ayuni Mohamed Pesri; Norlianah Mazalan; Intan Nureslyna Samsudin; Safarina Mohamad Ismuddin; Geeta Appannah; Malina Osman; Siti Yazmin Zahari Sham
- Publication Type:Journal Article
- Keywords:
atherogenic normolipidaemia;
cardiovascular risk;
small dense low-density lipoprotein cholesterol (sdLDL);
Pattern B
- From:The Malaysian Journal of Pathology
2020;42(2):215-225
- CountryMalaysia
- Language:English
-
Abstract:
Dyslipidaemia is a recognised conventional risk factor for cardiovascular disease (CVD).
However, even when traditional lipid parameters are normal, CVD risk can exist. Small dense lowdensity lipoprotein cholesterol (sdLDL) has appeared as a significant risk marker for CVD. This
study aimed to determine the prevalence and associated factors of atherogenic lipoprotein Pattern
B in the Malaysian population. Materials and Methods: This cross-sectional study included 150
subjects aged 30 years and above who attended a health screening in a Malaysian tertiary institution.
Sociodemographics, clinical characteristics and laboratory parameters (lipids, glucose, and sdLDL)
were obtained. Lipoprotein subfraction was analysed using the polyacrylamide gel electrophoresis
method. Results: Malays and females made up the majority of subjects and the median age was
37 years. Normolipidaemic Pattern B was significantly higher in women (p=0.008). Significant
independent predictors of Pattern B were gender (p=0.02), race (p=0.01), body mass index (BMI)
[p=0.02] and lipid status (p=0.01). Triglyceride was the only independent predictor of sdLDL (p=0.001).
Conclusion: The prevalence of Pattern B of 33% in this study was comparatively high, of which
6.7% were normolipidaemic. Chinese males with dyslipidaemia and increased BMI independently
predicted Pattern B. Differences in triglyceride levels alone among these ethnic groups do not fully
explain the differences in the prevalence of Pattern B although it was the only lipid parameter to
independently predict sdLDL. Individuals with atherogenic normolipidaemia are at greater risk
for a CVD event as they are not included in the protective measures of primary CVD prevention.
- Full text:5.2020my01064.pdf
