Therapeutic potentials of neural stem cells in Alzheimer’s disease
- Author:
Wong Rebecca S.Y
1
Author Information
1. Faculty of Medicine, SEGi University. No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia
- Collective Name:Soon-Keng Cheong
- Publication Type:Review
- Keywords:
Alzheimer’s disease;
neurogenesis;
neural stem cells;
neural progenitor cells
- From:The Malaysian Journal of Pathology
2020;42(2):157-170
- CountryMalaysia
- Language:English
-
Abstract:
The commonest cause of dementia among the elderly population is Alzheimer’s disease (AD). It
is a health concern globally as the number of people affected by dementia worldwide is rapidly
increasing. Several genes have been linked to AD and the pathogenesis of the disease has been
extensively and vigorously examined. Thus far, only a few drugs have been approved by the Food
and Drug Administration (FDA) for the pharmacological treatment of AD and a growing body
of research has turned to alternative options such as stem cell therapy. This review will give an
overview of the pathological and clinical aspects of AD. Although researchers have explored the
suitability and feasibility of using various types of stems cells to treat AD, this review will focus
mainly on neural stem cells (NSCs)/ neural progenitor cells (NPCs). The behaviour and properties
of NSCs will be described, accompanied by a comprehensive discussion of the therapeutic strategies
involving the use of NSCs/NPCs in the treatment of the disease
- Full text:5.2020my01058.pdf
