Role of pyroptosis in the pathogenesis of acute pancreatitis
10.3969/j.issn.1001-5256.2020.08.050
- VernacularTitle:细胞焦亡在急性胰腺炎发病机制中的作用
- Author:
Biwei WEI
1
;
Yahui GONG
1
;
Zhihai LIANG
1
Author Information
1. First Ward Area, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
- Publication Type:Research Article
- Keywords:
pancreatitis;
pyroptosis;
inflammasomes
- From:
Journal of Clinical Hepatology
2020;36(8):1905-1908
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis (AP) is a common gastrointestinal disease and may lead to local complications and even multiple organ failure, and the pathogenesis of AP involves self-digestion of trypsin, inflammatory response, and microcirculation disturbance. This article introduces the role of pyroptosis in the pathogenesis of AP and briefly describes the activation pathway of pyroptosis, inflammasome, and the mechanism of action of effector molecules in inducing damage to the pancreas and extra-pancreatic organs. It is believed that the regulation of pyroptosis plays an important role in the pathogenesis of AP, which provides new ideas for the prevention and treatment of AP.
