Current research on liver regeneration: Pathogenesis and serum markers
10.3969/j.issn.1001-5256.2020.08.048
- VernacularTitle:肝再生的发生机制及血清标志物的研究现状
- Author:
Jiani LI
1
,
2
;
Chuan HAN
1
;
Xiaoping WANG
1
,
2
;
Shanhong TANG
1
,
2
;
Weizheng ZENG
1
Author Information
1. Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, China
2. Southwest Jiaotong University, Chengdu 610083, China
- Publication Type:Research Article
- Keywords:
liver regeneration;
alpha-fetoproteins;
biomarkers
- From:
Journal of Clinical Hepatology
2020;36(8):1896-1899
- CountryChina
- Language:Chinese
-
Abstract:
Liver regeneration is an important response after liver injury and necrosis to maintain liver volume and function, with the involvement of various factors and signaling pathways. This process has three main stages, i.e., the initial stage of mitosis triggered by certain factors, the proliferation stage of promoting hepatocytes to enter the cell cycle, and the termination stage of promoting liver cells to reach a certain number and the recovery of liver mass. This article introduces various factors and multiple cellular signaling pathways that promote the differentiation of liver stem cells into liver cells to restore liver volume and function and summarizes the previous research findings of our group that alpha-fetoprotein is an important serum marker for liver regeneration after liver failure. The analysis shows that in-depth studies of the occurrence and clinical application of liver regeneration will help to improve the understanding of liver regeneration, better predict the prognosis of acute and chronic liver diseases, and provide new ideas and methods for the clinical diagnosis and treatment of various advanced liver diseases.
