Association of hypoxic microenvironment with the development and progression of liver diseases

VernacularTitle:缺氧微环境与肝病发生发展的关系
Author: Zhiguo LI ^{1
,

2} ; Xianzhao YANG ^{1
,

2} ; Xiaoke LI ^{1
,

2} ; Xun MA ³ ; Shan WANG ^{1
,

2} ; Mei ZHANG ⁴ ; Yongan YE ^{1
,

2}
Author Information

1. Department of Gastroenterology
2. Institute of Liver Diseases, Beijing University of Chinese Medicine, Beijing 100700, China
3. Beijing Xing Yuan Jin Fang Clinic of Chinese Medicine, Beijing 101300, China
4. Department of Clinical Laboratory, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China
Publication Type:Research Article
Keywords: liver diseases; hypoxic microenvironment; hypoxia-inducible factor
From: Journal of Clinical Hepatology 2020;36(8):1891-1895
CountryChina
Language:Chinese
Abstract: Hypoxic microenvironment is a common phenomenon of liver diseases and runs through the whole process of the development and progression of liver diseases. In recent years, the research on liver fibrosis and hypoxic microenvironment of hepatocellular carcinoma has attracted more and more attention. Hypoxia-inducible factor (HIF) is the most important hypoxic stress factor found at present. This article reviews the characteristics of hypoxic microenvironment in the liver and liver diseases and further elaborates on the association of HIF overexpression with hepatocyte damage, formation of fibrosis, and malignant transformation of hepatocytes.