Research advances in the pathogenesis of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2020.08.043
- VernacularTitle:非酒精性脂肪性肝病的发病机制研究进展
- Author:
Weisong XIAO
1
;
Yingyu LE
1
;
Shenglan ZENG
1
;
Xiaobin QIN
1
;
Cong WU
1
;
Dewen MAO
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine, Nanning 530222, China
2. First Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
lipid metabolism disorders;
gastrointestinal microbiome;
hypothalamus
- From:
Journal of Clinical Hepatology
2020;36(8):1874-1879
- CountryChina
- Language:Chinese
-
Abstract:
The development and progression of nonalcoholic fatty liver disease (NAFLD) have complex potential mechanisms. The traditional “two-hit” pathophysiological theory has been challenged, and in recent years, an increasing number of studies have been performed to investigate the interaction between insulin resistance, adipokines, and other unknown pathogenic factors in various organs. This article summarizes the factors of the liver, intestinal tract, hypothalamus, and extracellular cysts, as well as genetic factors, with an emphasis on the synergistic mechanism of action of the liver and extrahepatic organs in the pathogenesis of NAFLD, in order to provide a reference for obtaining new insights into NAFLD regulatory network and determining new targets for the prevention and treatment of NAFLD.
