Expression of HER-2 in colorectal cancer and its relationship with clinicopathological features and prognosis
10.3760/cma.j.issn.1007-631X.2019.12.013
- VernacularTitle:人表皮生长因子受体-2表达与结直肠癌临床病理特征及预后的关系
- Author:
Wulin WU
1
;
Zejian LYU
;
Zifeng YANG
;
Qian YAN
;
Yuwen LUO
;
Weijun LIANG
;
Deqing WU
;
Weixian HU
;
Guanfu CAI
;
Xueqing YAO
;
Yong LI
Author Information
1. 广东省人民医院广东省医学科学院普通外科
- Keywords:
Colorectal neoplasms;
Receptor,epidermal growth factor;
Pathology,clinical;
Prognosis
- From:
Chinese Journal of General Surgery
2019;34(12):1064-1067
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expression of (epidermal growth factor receptor-2,HER-2) and clinicopathological features and survival of colorectal cancer.Methods From Jan 2005 to Dec 2015,all colorectal cancer cases were enrolled that the expression levels of HER-2 were detected in Guangdong Provincial People's Hospital.Clinicopathological features of the tumors and survival of the patients were analyzed.Results A total of 1 463 cases were collected in 10 years,including 711 cases (48.6％) of HER-2 (-),470 cases (32.1％) of HER-2 (+),249 cases (17％) of HER-2 (+ +),and 33 cases (2.3％) of HER-2 (+ + +).Correlation analysis shows that the expression levels of HER-2 were significantly correlated with tumor differentiation and the depth of tumor invasion(T stage),but not correlated with gender,age,tumor location,N stage,M stage,TNM stage and overall survival,and disease-free survival.Conclusion The expression of HER-2 may be related to tumor differentiation and growth infiltration,but it cannot be used as a predictor of prognosis in patients with colorectal cancer.
