Outcome of long-term cognitive function after liver transplantation in children:role of age factor
10.3760∕cma.j.issn.0254-1416.2019.10.005
- VernacularTitle:小儿肝移植术后远期认知功能的转归:年龄因素在其中的作用
- Author:
Hui ZHU
1
;
Xuliang JIANG
;
Lili HUANG
;
Xiao ZHANG
;
Weitian TIAN
;
Diansan SU
;
Weifeng YU
Author Information
1. 苏州大学医学部 215123
- Keywords:
Liver transplantation;
Cognition;
Child;
Age factors
- From:
Chinese Journal of Anesthesiology
2019;39(10):1165-1167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the outcome of long-term cognitive function after liver transplan-tation in children and the role of age factor.Methods Ninety-five pediatric patients,aged 2 yr and 6 months to 6 yr and 11 months at test,at least 1 yr after liver transplantation,were selected.The children's cognitive function was assessed using Chinese Wechsler Intelligence Scale for Children.The patients were divided into 2 groups according to the age at transplantation: ≤1 yr group(L1 group,n＝65)and > 1 yr group(M1 group,n＝22).Results Compared with the normal value,the scores of verbal comprehension and total intelligence quotient(IQ)were significantly decreased,and the proportion of children who had a-bove-average IQ was decreased 1 yr after liver transplantation,the scores of verbal comprehension were de-creased,and the proportion of children who had above-average IQ was decreased in group L1,and the scores of verbal comprehension,visual space and total IQ were significantly decreased,the proportion of children who had above-average IQ was reduced,and the proportion of children who had below-average IQ was increased in group M1(P＜0.05).Compared with L1 group,the total IQ score was significantly de-creased,the proportion of children who had above-average IQ was reduced,and the proportion of children who had below-average IQ was increased in group M1(P＜0.05).Conclusion The long-term cognitive function of children after liver transplantation is lower than that of normal children,and the long-term cogni-tive function of children ≤1 yr is better than that of children >1 yr.
