Research advances of oncolytic viruses promoting autophage in tumor cells
10.3969/j.issn.1000-8179.2019.18.059
- VernacularTitle:溶瘤病毒促进肿瘤细胞自噬的研究进展
- Author:
Kai ZHANG
1
;
Binlei LIU
;
Hengning KE
Author Information
1. 武汉大学中南医院感染科
- Keywords:
autophage;
oncolytic virus;
tumor cell
- From:
Chinese Journal of Clinical Oncology
2019;46(18):957-961
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a physiological process of normal cells that is activated in response to accumulation of abnormal proteins, damaged organelles, and cell starvation and involves their transport to lysosomes for degradation and recycling, enabling the mainte-nance of cellular homeostasis. Oncolytic viruses, which are obtained from naturally occurring or genetically modified viruses, specifical-ly target and kill tumor cells. Despite receiving much attention, the mechanisms underlying this process remain unclear, although re-cent studies have implicated autophagy in the phenomenon. Here we outline how oncolytic viruses cause cell death via autophagy and how they can be exploited for the treatment of cancer.
