Clinical analysis of third-line combination therapy with S-1 plus apatinib for advanced colorectal cancer
10.3969/j.issn.1000-8179.2019.18.909
- VernacularTitle:替吉奥联合阿帕替尼三线治疗晚期肠癌患者的临床观察
- Author:
Yuhong DAI
1
;
Li SUN
;
Tingting HUANG
;
Hong QIU
Author Information
1. 华中科技大学同济医学院附属同济医院肿瘤中心消化系统肿瘤科
- Keywords:
colorectal cancer;
S-1;
apatinib;
adverse events;
clinical observation
- From:
Chinese Journal of Clinical Oncology
2019;46(18):945-948
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the efficacy and toxicity of apatinib combined with S1 as a third-line therapy for advanced colorectal cancer. Methods: Forty-four patients with adavanced colorectal cancer from Tongji Hospital Cancer Center were enrolled from April 2016 to August 2018. The median follow-up period was 8 months. Data related to efficacy and adverse effects were recorded. Results: The median progression-free survival (PFS) time was 3.93 months (95%CI: 2.72-5.15 months), and the median overall survival (OS) time was 7.77 months (95%CI: 5.36-10.18 months). Patients with left hemicolon cancer and rectal cancer group had a longer PFS than patients with right hemicolon cancer group (4.94 months vs . 3.89 months, P=0.024); the OS for left hemicolon cancer and rectal cancer was 12.5 months, the OS for right hemicolon cancer was 7.4 months, P=0.080; gender, previous bevacizumab use and liver metastasis had no statistically significant effect on PFS and OS; the PFS was 4.48 months and 1.10 month, in the patients with ECOG 0-1 and ECOG 2; the OS was 9.67 months and 2.90 month, in these two groups respectively. The major adverse effects of the combination therapy were fatigue (52.3%), hypertension (45%), hand-foot syndrome (22.7%), leukopenia (15.9%), and neutropenia (15.9%), thrombocytopenia (22.7%), elevated transaminase levels (13.6%), diarrhea (15.9%). Conclusions: The results suggest that the combination of apatinib and S-1 is safe and effective as a third-line treatment for advanced colorectal cancer.
