Novel analgesic targets and corresponding analgesic leading compounds
10.3867/j.issn.1000-3002.2019.12.006
- VernacularTitle:新的镇痛靶点及相应的镇痛先导化合物
- Author:
Bo-Yang ZHENG
1
;
Rui-Hong ZENG
Author Information
1. 河北医科大学免疫学教研室
- Keywords:
analgesic;
target;
agonist;
antagonist;
leading compound
- From:
Chinese Journal of Pharmacology and Toxicology
2019;33(12):1057-1065
- CountryChina
- Language:Chinese
-
Abstract:
Opioid medications have been used for pain management, but there are negative side effects, including a potential delay in recovery and increased risk of permanent disability. In this paper, analgesic targets including N-methyl-D-aspartate receptors, cannabinoid receptors, prostaglandin E2 receptor 4 receptors, matrix metalloproteinase receptors, and some new targets for blocking pain signaling pathways associated with these receptors are reviewed. In addition, some novel agonists, antagonists, and leading compounds with agonistic (antagonistic) activities interacting with the target are also described. These novel compounds usually have better analgesic activity and lower side effects than traditional opioids. They are expected to be developed into new analgesics and benefit clin?ical patients who need pain treatment.
