Comparisons of exploratory eye movement, adrenocorticotropic hormone and cortisol levels in bipolar and unipolar depression aged patients.
10.3969/j.issn.1002-0152.2019.11.002
- VernacularTitle:老年单双相抑郁障碍探索性眼球运动和促肾上腺皮质激素及皮质醇水平比较
- Author:
Wenfeng ZHEN
1
;
Xin MA
;
Hongxing WANG
Author Information
1. 首都医科大学附属北京安定医院
- Keywords:
Eldly;
Bipolar depression;
Unipolar depression;
Exploratory eye movement;
ACTH COR
- From:
Chinese Journal of Nervous and Mental Diseases
2019;45(11):647-651
- CountryChina
- Language:Chinese
-
Abstract:
To explore the characteristics of exploratory eye movement (EEM) and hypothalamic-pituitary-adrenal axis (HPA) in elderly patients with acute bipolar and unipolar depression. Methods Thirty-eight elderly patients with bipolar depression (bipolar group) and thirty-nine patients with unipolar depression (unipolar group) were enrolled. The 24-item Hamilton depression rating scale (HAMD-24) was used to evaluate depressive symptoms. The levels of peripheral serum adrenocorticotropic hormone (ACTH) and cortisol (COR) were detected. EEM was recorded to obtain the number of eye fixation (NEF), responsive search score (RSS) and discriminant analysis (D). Results Compared with the unipolar group, the bipolar group had earlier onset, longer duration, and more admissions (P＜0.05). In comparison with the bipolar group, the unipolar group had higher levels of ACTH and COR (P＜0.05), and higher abnormal proportion of COR and ACTH levels. D-values were higher and RSS-values were lower in unipolar group than in bipolar group. There were no significant differences in NEF and HAMD total scores and its subfactors between the two groups (P＞0.05). Correlation analysis showed that the D value of unipolar group was positively correlated with COR level (r=0.482, P=0.002) but not with other indexes (P＞0.05). There were no significant correlations between EEM parameters and serum levels of HPA hormones in bipolar group (P＞0.05). Conclusion There are different clinical features, EEM indicators, the serum levels of ACTH and COR between acute unipolar and bipolar depression, which suggests the heterogeneity between the two diseases.
