Radiation induced mucositis and its relationship with nutritional status in head and neck cancer patients treated with radiotherapy
10.3760/cma.j.issn.1674-635X.2019.06.007
- VernacularTitle:头颈部恶性肿瘤放射治疗患者放射性黏膜炎及其与营养状况的关系
- Author:
Lichuan ZHANG
1
;
Yujie WANG
;
Bing ZHUANG
;
Hongmei LI
;
Liqing GONG
;
Yanli WANG
;
Yu FANG
;
Yan SUN
;
Shaowen XIAO
;
Baomin ZHENG
;
Qian LU
Author Information
1. 100191,北京大学护理学院
- Keywords:
Head and Neck Cancer;
Radiation Induced Mucositis;
Pain;
Diet Pattern;
Weight
- From:
Chinese Journal of Clinical Nutrition
2019;27(6):367-373
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the characteristics of radiation induced mucositis in patients withhead and neck cancer ( HNC) during radiotherapy, and analyze the effect of radiation induced mucositis on diet patterns and weight change and the influencing factors for radiation induced mucositis. Methods Patients with HNC treated with radiotherapy in one cancer hospital were recruited. Data were collected before, during and at the end of the radiotherapy, which included radiation induced oral and pharyngeal mucositis, pain during eat-ing, diet patterns and weight. Results Two hundred and two patients were completely investigated and 43.5％and 34. 2％ of the patients suffered from moderate to severe (≥grade 2) oral mucositis and pharyngeal mucosi-tis, respectively during the radiotherapy. At the end of radiotherapy, 53. 5％ and 51. 5％ of the patients suffered from moderate to severe oral mucositis and pharyngeal mucositis (≥grade 2 ) , respectively. Oral and pharyngeal mucositis were significantly correlated with pain during eating, diet patterns and weight ( P<0. 05) . Tumor site was the main reason that affected the severity of mucositis ( Wald χ2 =26. 033, 14. 216;P<0.001). Conclusion Radiation induced mucositis was gradually aggravated with radiotherapy progress, which is closely related to pain during eating, change of diet patterns and weight loss. The severity of mucositis is re-lated to the tumor site. Measures should be taken to strengthen the management of adverse reactions and nutri-tional status of patients.
