Effects of vitamin D3 supplementation combined with standardized hypoglycemic regimen on islet β cell function and macrovascular complications in newly diagnosed type 2 diabetes mellitus
10.3760/cma.j.issn.1674-635X.2019.06.005
- VernacularTitle:维生素D3补充联合规范化降糖方案对初诊2型糖尿病患者胰岛β细胞功能及大血管并发症的影响
- Author:
Shiwei LIU
1
,
2
;
Ruixue DUAN
;
Xin LI
;
Jiaxin ZHANG
;
Yaru WU
;
Yu ZHANG
Author Information
1. 030032 太原,山西白求恩医院内分泌科
2. 030009 太原,山西医科大学附属太原市中心医院中心实验室
- Keywords:
Type 2 diabetes;
Vitamin D;
Islet Cell Function;
Macroangiopathy;
Vaspin
- From:
Chinese Journal of Clinical Nutrition
2019;27(6):354-360
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of vitamin D3 supplementation combined with standard-ized hypoglycemic regimen on islet β cell function and macroangiopathy of T2DM patients. Methods A total of 192 patients with type 2 diabetes mellitus were selected and randomly divided into control group and observation group with 96 patients in each group. Patients in two groups were given standardized hypoglycemic regimen, and the observation group was treated with vitamin D3 supplementation in addition. The changes of the indexes of body examination, glycolipid metabolism, islet β cell function and macrovascular complications before and 6 months after treatment were compared between the two groups. Results After 6 months of treatment, BMI, SBP, TG, FBG, FINS, HbA1c and HOMA-IR decreased, while HOMA-β increased in both groups ( P<0. 05) . Compared with the control group, the serum levels of 25 ( OH) D increased, and vaspin and CRP de-creased significantly after 6 months of treatment in the observation group ( P<0. 05) . CIMT and other indicators showed no significant difference. 25 (OH) D was negatively correlated with FBG, FINS, vaspin and CRP, and positively correlated with 1PH and ISI (P<0.05). Conclusion Vitamin D3 is closely related to T2DM and its macrovascular complications, but it has not been found that vitamin D3 supplementation can further improve islet β cell function and macrovascular complications in patients with T2DM.
