Effect of vitamin D intervention on the outcome of glucose metabolism in patients with impaired glucose regulation
10.3760/cma.j.issn.1674-635X.2019.06.004
- VernacularTitle:小剂量维生素D对葡萄糖调节受损患者糖代谢结局的影响
- Author:
Jingjing LU
1
;
Yeqing LIU
;
Jie ZHANG
;
Pingping LOU
;
Yan LIU
;
Yaru ZHOU
Author Information
1. 河北医科大学第三医院内分泌科
- Keywords:
vitamin D;
25( OH) D3;
type 2 diabetes mellitus;
insulin secretion
- From:
Chinese Journal of Clinical Nutrition
2019;27(6):349-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the intervention effect of low-dose vitamin D on glucose metabolism of patients with impaired glucose regulation. Methods A total of196 subjects receiving oral glucose tolerance test were enrolled in this study, including individuals with normal glucose tolerance ( NGT group, n=67) and indi-viduals with impaired glucose regulation (IGR group, n=129). The IGR group was divided into intervention group ( n=64) and non-intervention group ( n=65) according to vitamin D intervention ( for 1 year) performed or not. Clinical data and biochemical parameters were collected. Results The level of serum 25(OH)D3 was significantly lower in the IGR group than that of normal control group ( P<0. 05) . After 1 year of low-dose vita-min D intervention, insulin sensitivity increased and insulin resistance decreased in the intervention group as compared with non-intervention group. Diabetes developed less frequently in the intervention group ( 25 of 64 [ 39. 1％] ) compared with non-intervention group ( 30 of 65 [ 46. 2％] ) . But there was no significant differ-ent in diabetes prevalence between the two groups. Conclusions Vitamin D intervention can improve insulin sensitivity and reduce insulin resistance in patients with impaired glucose regulation. Low dose vitamin D can improve the abnormal glucose metabolism outcome in patients with impaired glucose regulation.
