Differences of gut microbiota between type 2 diabetes and non-diabetic population
10.3760/cma.j.issn.1674-635X.2019.06.003
- VernacularTitle:2型糖尿病患者与非糖尿病人群肠道菌群差异的研究
- Author:
Shixuan LIU
1
;
Yong XUE
;
Tao YUAN
;
Yong FU
;
Naishi LI
;
Yingyue DONG
;
Baoli ZHU
;
Weigang ZHAO
Author Information
1. 国家卫生健康委员会内分泌重点实验室
- Keywords:
Type 2 diabetes;
Gut microbiota;
Metagenome analysis
- From:
Chinese Journal of Clinical Nutrition
2019;27(6):342-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the difference of gut microbiota between type 2 diabetes mellitus (T2DM) and non-diabetic population in Beijing. Methods 83 T2DM patients were selected as T2DM group and 64 non-diabetic subjects were selected as control group. Fecal samples were collected from all the subjects. The intestinal flora was detected by metagenome sequencing technology. Results 11 bacterialphyla were detec-ted in the two groups, there were significant differences in species diversity of Actinobacteria (P=0. 013), Firmicutes (P=0. 005), Fusobacteria (P=0. 001), Proteobacteria (P<0. 001) between the two groups. Actinobacteria, Fusobacteria and Proteobacteria were all enriched in the T2DM group, Firmicutes were enriched in the control group. 152 bacterial genera were detected in the two groups with 31 bacterial genera ofsignificant differences. In T2DM group, the levels of Roseburia, Eubacterium and Faecalibacterium decreased, while the levels of Bifidobacterium, Lactobacillus and Escherichia increased. Conclusion There are significant differ-ences in the composition of gut microbiota between T2DM patients and non-diabetic population. Regulation of gut microbiota in T2DM patients may be helpful to improve the condition of T2DM.
