Results of Three-Dimensional Conformal Radiation Therapy for the Treatment of a Solitary Sternal Relapse of Breast Cancer.
- Author:
Haeyoung KIM
1
;
Seung Jae HUH
;
Won PARK
;
Do Ho CHOI
;
Min Kyu KANG
;
Jung Hyun YANG
;
Seok Jin NAM
;
Young Hyuck IM
Author Information
1. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. sj5201.huh@samsung.com
- Publication Type:Original Article
- Keywords:
Solitary sternal relapse;
Three-dimensional conformal radiotherapy;
Breast cancer
- MeSH:
Breast;
Breast Neoplasms;
Follow-Up Studies;
Humans;
Recurrence;
Survival Rate;
Tumor Burden
- From:The Journal of the Korean Society for Therapeutic Radiology and Oncology
2008;26(2):91-95
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the response and survival rate after three-dimensional conformal radiation therapy (3D-CRT) of patients with a solitary sternal relapse of breast cancer. MATERIALS AND METHODS: Seventeen patients between May 1996 and June 2005 were evaluated with the salvage 3D-CRT treatment of a solitary sternal relapse of breast cancer. The treatment fields included the gross tumor volume with 2 cm margins. The total radiation dose was 35.0~61.5 Gy (biologic effective dose of 43.7 ~76.9 Gy(10) using an alpha/beta ratio of 10 Gy), with a daily dose of 1.8~3.0 Gy. The tumor response was evaluated by the change in maximum tumor size via follow up CT scans 1~3 months after the completion of treatment. RESULTS: An objective tumor response was achieved in all patients, with a complete response in 5 patients and a partial response in 12 patients. The 5-year overall survival rate was 51.9% (median survival time: 27 months), and the most important factor affecting overall survival was the disease-free interval (interval from primary surgery of breast cancer to the development of sternal metastasis): The 5-year overall survival rate was 61.8% for patients with a disease-free interval > or =12 months and 0.0% for patients with disease-free interval <12 months (p=0.03). CONCLUSION: The response to 3D-CRT was good in patients with solitary sternal relapse of breast cancer. Particularly, patients with long disease-free interval from primary surgery survived significantly longer than patients with short disease-free interval from primary surgery.
