Research progress in 3D cell culture model of ovarian cancer tumor microenvironment
10. 11904/j. issn. 1002-3070. 2019. 06. 016
- VernacularTitle:卵巢癌肿瘤微环境的三维细胞培养模型研究进展
- Author:
Jian XU
1
;
Yueping ZHAN
;
Yuanye JIANG
;
Qin CAO
Author Information
1. 上海中医药大学附属普陀医院(上海 200062
- Keywords:
Ovarian cancer;
Tumor microenvironment;
3D cell culture models
- From:Practical Oncology Journal
2019;33(6):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian cancer(OC)is an aggressive and fatal cancer. A growing number of studies have shown that the tumor mi-croenvironment(TME)is involved in the promotion and development of ovarian cancer,immunosuppression and inflammatory response through various mechanisms. TME includes tumor blood vessels and lymphatic vessels,as well as cancer cells,mesenchymal cells,im-mune cells,and extracellular matrix(ECM). Based on recent literature reports,this paper reviews the commonly used three-dimen-sional(3D)cell culture model of ovarian tumor microenvironment,and summarizes many 3D models that do not contain primitive stro-mal cells,aiming to find new approaches for ovarian cancer treatment.
