Expression of MAP1A in bladder cancer and its correlation with clinicopathological features
10. 11904/j. issn. 1002-3070. 2019. 06. 009
- VernacularTitle:MAP1 A在膀胱癌组织中的表达及其与临床病理特征的关系
- Author:
Jinhai FAN
1
;
Yumei JIANG
;
Jing ZHANG
;
Xiaojing BAI
Author Information
1. 西安交通大学第一附属医院泌尿外科(西安 710061
- Keywords:
Bladder cancer;
Microtubule associated protein 1A;
Clinicopathological features;
Prognosis
- From:
Practical Oncology Journal
2019;33(6):525-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective The objective of this study was to investigate the expression of microtubule associated protein 1A (MAP1A)in bladder cancer and its correlation with clinicopathological features. Methods One hundred and thirty seven cases of bladder cancer and adjacent tissues were collected. qRT -PCR and immunohistochemistry were used to analyze the expression of MAP1A in bladder cancer and adjacent tissues. The relationship between the expression of MAP1A and clinicopathological parameters& prognosis of bladder cancer patients was studied. Results The results of qRT-PCR showed that the expression level of MAP1A in 20 cases of bladder cancer was significantly lower than that of the matched adjacent tissues(t=5. 022,P<0. 001). The results of im-munohistochemistry also showed that the positive expression rates of MAP1A in bladder cancer and adjacent tissues were 46. 71% (46/37)and 79. 56% (109/137),respectively,and the difference was statistically significant(χ2 =23. 52,P<0. 0001). The expres-sion of MAP1A was closely related to clinical T stage,lymph node metastasis and TNM stage(χ2 =9. 982,P=0. 0016;χ2 =8. 064,P=0. 0045;χ2 =7. 199,P<0. 0073). Kaplan-Meier survival analysis showed that the overall survival(OS)and disease-free survival (DFS)of patients with low expression of MAP1A were significantly shorter than those with high expression of MAP1A(χ2 =26. 74,P<0. 0001;χ2 =18. 73,P<0. 0001). Cox multivariate regression analysis showed that TNM stage(HR=1. 46,P=0. 038)and MAP1A expression(HR=1. 213,P =0. 030) were independent risk factors for adverse prognosis of bladder cancer patients. Conclusion MAP1A is significantly down-regulated in bladder cancer tissues and is closely related to clinical TNM staging. The low expression of MAP1A may indicate the poor prognosis of bladder cancer patients.
