Expression of ACSL4 in gastric cancer tissues and its correlation with prognosis
10.3760/cma.j.issn.1673-4181.2019.06.004
- VernacularTitle:胃癌组织中ACSL4的表达情况及其与预后的相关性
- Author:
Wangqing ZHANG
1
;
Juan LIU
Author Information
1. 天津市北辰医院消化内科 300400
- Keywords:
Gastric cancer;
Immunohistochemistry;
ACSL4;
pTNM staging;
Prognosis
- From:
International Journal of Biomedical Engineering
2019;42(6):474-478
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of ACSL4 in human gastric cancer tissue and to analyze its clinical significance. Methods The bioinformatics method was used to analyze the mRNA level of ACSL4 in gastric cancer tissues and normal tissues, and to analyze the relationship between its expression and disease-free survival rate of gastric cancer patients. The clinical and pathological data of 62 patients with gastric cancer who underwent surgical treatment were retrospectively analyzed. Immunohistochemistry was used to detect the expression of ACSL4 protein in gastric cancer tissues and adjacent tissues, and to analyze its relationship with clinicopathological characteristics of gastric cancer patients. Results The results of bioinformatics analysis showed that the mRNA of ACSL4 was significantly overexpressed in gastric cancer tissues, and was significantly related to the disease-free survival rate of patients. Immunohistochemical results showed that ACSL4 was mainly cytoplasmic and highly expressed in gastric cancer tissues, while low or no expression in adjacent tissues. The protein expression level of ACSL4 was related to tumor size and pTNM (all P<0.05), but not to the patient's age, gender and tumor grade (all P>0.05). Conclusions The expression of ACSL4 in gastric cancer tissues is abnormally increased, and it is related to tumor size and pTNM stage. The results of this study suggest that the expression of ACSL4 is related to the prognosis of patients.
