Systematic Evaluation of the Preventive Effect of Dexmedetomidine on Adverse Drug Reactions Caused by Carboprost Tromethamine During Cesarean Section
- VernacularTitle:右美托咪定在剖宫产术中预防卡前列素氨丁三醇不良反应的系统评价
- Author:
Lingxi KONG
1
;
Hongmei WANG
1
;
Feng QIU
1
;
Xuefeng SHAN
1
;
Yingying REN
2
;
Yang YANG
2
Author Information
1. Dept. of Pharmacy，the First Affiliated Hospital of Chongqing Medical University，Chongqing 400016，China
2. Dept. of VIP Anesthesiology，Jinshan Hospital，the First Affiliated Hospital of Chongqing Medical University，Chongqing 400016，China
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Cesarean section;
Carboprost tromethamine;
Adverse drug reactions;
Meta-analysis
- From:
China Pharmacy
2020;31(15):1901-1905
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To evaluate the preventive effect of dexmedetomidine （DEX）on adverse drug reactions induced by carboprost tromethamine used in cesarean section ，and to provide evidence-based reference for rational drug use of cesarean section. METHODS：Retrieved from PubMed ，Cochrane library ，Embase，CNKI，CBM，Wanfang database and VIP during inception to June of 2019，randomized controlled trials about DEX （trial group ）versus normal saline （control group ）in the prevention of adverse drug reactions induced by carboprost tromethamine in cesarean section were collected. After data extraction of included literatures and quality evaluation with modified Jadad scale ，Meta-analysis was performed by using Rev Man 5.3 statistical software. RESULTS ：A total of 11 RCTs with 714 patients were included in this study. Results of Meta-analysis showed that the incidence of nausea [OR ＝0.09，95％CI（0.06，0.14），P＜0.000 01]，vomiting [OR ＝0.09，95％CI（0.05，0.15），P＜0.000 01]， facial flushing [OR ＝0.15，95％CI（0.10，0.22），P＜0.000 01]，chest distress [OR ＝0.12，95％CI（0.08，0.18），P＜0.000 01]， hypertension [OR ＝0.06，95％CI（0.04，0.11），P＜0.000 01] and tachycardia [OR ＝0.17，95％CI（0.12，0.25），P＜0.000 01] in trial group were significantly lower than control group ，with statistical significance. CONCLUSIONS ：DEX can reduce adverse drug reactions such as nausea and vomiting caused by carboprost tromethamine used in cesarean section.
