Research progress of circular RNA and its research prospects in oral diseases
- Author:
ZENG Bing-hui
1
;
YU Dong-sheng
1
Author Information
- Publication Type:Review
- Keywords: Circular RNA; Tumor; Oral diseases; miRNA sponge; Biomarker
- From: Journal of Prevention and Treatment for Stomatological Diseases 2017;25(2):123-128
- CountryChina
- Language:Chinese
- Abstract: Circular RNAs (circRNAs) are RNAs with a covalently closed loop structure, characterized by its conservation, stability, tissue specific and ubiquity. CircRNAs can serve as miRNA ‘sponges’ to modulate the mRNA targets of miRNAs. CircRNAs can bind with RNA binding proteins and regulate the expression of some genes. The differential expression of circRNAs between pathogenic and normal tissues makes circRNAs possibly promising biomarkers for diagnosis and targets for treatment. In this article, we reviewed the research progress of circRNA and discussed its research prospects in oral diseases.
- Full text:环状RNA研究进展及其在口腔疾病中的研究展望.pdf
