Research progress on the role of bile acids in regulating glycolipid metabolism
10.16438/j.0513-4870.2020-0781
- VernacularTitle:胆汁酸与糖脂代谢的研究进展
- Author:
Heng-cai YU
1
,
2
;
Shao-cong HOU
1
;
Bing CUI
1
;
Ping-ping LI
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
- Publication Type:Research Article
- Keywords:
bile acid;
glycolipid metabolism;
intestine;
farnesoid X receptor;
transmembrane G protein-coupled receptor 5
- From:
Acta Pharmaceutica Sinica
2020;55(7):1419-1430
- CountryChina
- Language:Chinese
-
Abstract:
Bile acids (BAs) are increasingly being appreciated as signaling molecules. Studies have shown that BAs regulate glucose and lipid metabolism mainly through the intracellular nuclear receptor farnesoid X receptor (FXR) and the transmembrane G protein-coupled receptor 5 (TGR5). FXR and TGR5 are highly expressed in the intestine. This article summarizes the synthesis, circulation, and regulation of BAs, as well as the effects of BAs on glycolipid metabolism through activation of liver FXR and inhibition or activation of intestinal FXR and TGR5. Furthermore, we illustrate the molecular mechanism of BAs on glycolipid metabolism by the relevant signaling pathways, including small heterodimer partner (SHP), fibroblast growth factor 15/19 (FGF15/19), ceramide and glucagon like peptide-1 (GLP-1). This review may serve as a reference for basic and clinical studies.
