Research advances in the transformation of chronic obstructive pulmonary disease to lung cancer
10.16438/j.0513-4870.2020-0170
- VernacularTitle:慢性阻塞性肺疾病转化为肺癌的研究进展
- Author:
Wen-min ZHOU
1
;
Qiao-ru GUO
1
;
Hui WANG
2
;
Zeng-bao WU
3
;
Jian-ye ZHANG
1
,
4
Author Information
1. Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China
2. Guangzhou Institute of Pediatrics/Guangzhou Women and Children′s Medical Center, Guangzhou Medical University, Guangzhou 510623, China
3. Key Laboratory of Xinjiang Phytomedicine Resources of Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832003, China
4. Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou 571199, China
- Publication Type:Research Article
- Keywords:
chronic obstructive pulmonary disease;
lung cancer;
epidemiology;
signal transduction;
rug therapy
- From:
Acta Pharmaceutica Sinica
2020;55(7):1410-1418
- CountryChina
- Language:Chinese
-
Abstract:
The incidence and mortality of chronic obstructive pulmonary disease (COPD) and lung cancer are increasing year by year, which are causing massive social and financial burdens around the world. An increasing number of investigations indicate the possibility of COPD transforming into lung cancer. The pathogenesis of these two diseases have some common aspects, such as epithelial-mesenchymal transition, chronic inflammation, DNA damage, impaired immune system, oxidative stress and tumor angiogenesis, which are heavily complicated. This review summarizes the epidemiological connection between COPD and lung cancer, the molecular-level transformation mechanism as well as the therapeutic strategy. Exploring the transformation mechanism and related signaling pathway of COPD to lung cancer can contribute to block the risk factors for the transformation and provide guidance for the novel drug development and drug therapy.
