Research progress of P450 in the biosynthesis of bioactive compound of medicinal plants

VernacularTitle:药用植物活性成分生物合成中P450的研究进展
Author: Ying MA ¹ ; Yuan CAI ² ; Xiao-jing MA ¹ ; Guang-hong CUI ¹ ; Jin-fu TANG ¹ ; Wen ZENG ¹ ; Shui-han ZHANG ² ; Juan GUO ¹ ; Lu-qi HUANG ¹
Author Information

1. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. Institute of Traditional Chinese Medicine, Hunan Academy of Traditional Chinese Medicine, Changsha 410006, China
Publication Type:Research Article
Keywords: cytochrome P450; medicinal plant; secondary metabolite; biosynthetic pathway
From: Acta Pharmaceutica Sinica 2020;55(7):1573-1589
CountryChina
Language:Chinese
Abstract: Most of the active ingredients of herbs are secondary metabolites of plants. Cytochrome P450s (P450s) are hemoglobin-containing monooxygenases encoded by a super-gene family, which play important roles in the metabolic network of plants. This review focuses on the role of P450s on biosynthesis of secondary metabolites such as terpenoids, alkaloids, flavonoids and phenylpropanoids. This will provide references for biosynthesis and regulation of secondary metabolites in medicinal plants.