Strategy for the identification and quantitative analysis of the phytochemicals of traditional Chinese medicine by LC-MS/MS
10.16438/j.0513-4870.2019-0973
- VernacularTitle:基于液质联用技术的中药植化成分研究方法与策略
- Author:
Pan YAN
1
;
Shuai-long JIA
1
;
Sen LI
2
;
Zhi-feng DU
1
;
Hong-liang JIANG
1
Author Information
1. Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China
2. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine;
phytochemicals;
LC-MS/MS;
fragmentation rule;
quality control
- From:
Acta Pharmaceutica Sinica
2020;55(7):1494-1503
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine (TCM) has made numerous contributions to the prosperity of China. However, the phytochemicals of TCM are complex, and there are significant differences in relative content. The material basis of TCM has restricted the modernization of TCM. Liquid chromatography-mass spectrometry (LC-MS) combines the high separation performance of chromatography and the high sensitivity of mass spectrometry. It has been widely used in the analysis of natural medicines and can greatly promote the development of TCM. Many studies have focused on the comprehensive characterization of phytochemicals, building a strategy for the rapid, accurate and systematic analysis of the chemical components of TCM through the integration of different mass spectrometric techniques, and laying the foundation for quality control and rational utilization of TCM.
