Association of PLCB1 gene polymorphism with the risk of central precocious puberty in Chinese Han girls
10.16835/j.cnki.1000-9817.2020.07.023
- VernacularTitle:PLCB1基因多态性与中国汉族女童中枢性性早熟的关联性
- Author:
LI Di, LUO Qingshan, CHEN Dingyan, WU Yu, HUANG Yuanyuan, LI Yingying, SU Zhe, ZHOU Li
1
Author Information
1. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan (430030), China
- Publication Type:Journal Article
- Keywords:
Genes;
Puberty,precocious;
Growth and development;
Reression analysis;
Child;
Female
- From:
Chinese Journal of School Health
2020;41(7):1040-1043
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between mutation of PLCB1, the downstream gene of KISS1/GPR54 pathway, and the risk of central precocious puberty (CPP) in Chinese Han girls.
Methods:Totally 169 pairs of CPP girls on their first visit to hospital and age-matched controls (± 3 months) were recruited. The genotypes of rs6140544, rs11476922, rs3761170 and rs2235613 were determined and the effect of loci variations on CPP was investigated.
Results:After adjusting for confounding factors (BMI, maternal age at menarche, maternal age at birth, and time for bed), rs2235613 variation was significantly negative associated with CPP in recessive models(OR=0.46，95%CI=0.24-0.91), and mutation in rs3761170 increased the risk of CPP in dominant models (OR=1.99，95%CI=1.01-3.93).
Conclusion:The study suggests that mutation in rs3761170 increases the risk of CPP and rs2235613 variation may have a protective effect on the risk of CPP.
