A cohort study on treatment outcomes of 1 447 cases with multidrug-resistant pulmonary tuberculosis
10.3969/j.issn.1006-2483.2020.02.017
- VernacularTitle:1447例耐多药肺结核患者治疗转归队列分析
- Author:
Mengxian ZHANG
1
;
Chenfeng YANG
1
;
Jianjun YE
1
;
Yu ZHANG
1
;
Yeqing TONG
1
;
Liping ZHOU
1
;
Shuangyi HOU
1
Author Information
1. Institute for Infectious Disease Control and Prevention, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079
- Publication Type:Journal Article
- Keywords:
Pulmonary tuberculosis;
Multidrug-resistant;
Treatment;
Analysis
- From:
Journal of Public Health and Preventive Medicine
2020;31(3):68-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the treatment outcomes of multidrug-resistant pulmonary tuberculosis (MDR-TB) cases in Hubei Province. Methods From October 2006 to June 2017, a retrospective cohort analysis of treatment outcomes for 1 447 patients with MDR-TB who were included in treatment was performed. Excel worksheet was created to establish database by monthly and quarterly reports. The statistical analysis of data was conducted using SPSS 21.0 software. Results Among 1 447 MDR-TB patients, 1 076 were males and 371 were females, with an average age of 44.44±14.28 years. 798 patients were cured, 63 patients completed the course of treatment, and the overall treatment success rate was 59.50% (861/1 447). The treatment success rate was68.02% (268/394) in newly diagnosed cases, and 56.32% (593/1 053) in relapse cases. There was a significance difference between the two groups (χ2=16.30，P<0.05). The treatment success rate [78.41% (672/857)] in patients with negative sputum culture at the end of 6th month was higher than the rate [38.71% (12/31)] of negative sputum culture at the end of 12nd month, with a statistical significance difference (χ2=26.65，P<0.05). The treatment success rate [12.07% (14/116)] in patients with continued positive sputum culture at the end of 6th month was higher than the rate [4.44% (2/45)] of negative sputum culture at the end of 12th month, with a significance difference (χ2=1.34，P=0.25). Conclusion It is extremely important to screen drug-resistant individuals for smear-positive patients, and to detect and treat drug-resistant patients timely. The negative conversion of sputum bacteria at the end of 6th month had important predictive significance for the treatment outcomes of MDR-TB patients. The patients with continued positive sputum at the end of 6th month should be closely monitored to adjust treatment according to the progress of the patient's condition and to explore a way to shorten the treatment course.
