Monitoring analysis of tuberculosis-related antibodies and and risk assessment of tuberculosis in Baotou region , 2012-2016
10.3969/j.issn.1006-2483.2020.03.011
- VernacularTitle:2012-2019年包头地区肺结核患者抗TBGL与抗LAM抗体的监测分析及风险评估
- Author:
Li SUN
1
;
Ming BAO
2
;
Min WU
1
Author Information
1. Department of Respiratory and Critical Care Medicine, Mongolia Baogang Hospital, Baotou，Inner Mongolia 014010, China
2. The Fourth Hospital of Baotou City, Baotou，Inner Mongolia 014030, China
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
Epidemiological investigation;
Antibody diagnosis;
Risk of recurrence;
Drug resistance
- From:
Journal of Public Health and Preventive Medicine
2020;31(3):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the monitoring analysis of pulmonary tuberculosis related antibodies and conduct and risk assessment of tubercuosis. Methods A total of 39 605 patients who were treated in Baotou tuberculosis prevention and treatment center from January 2012 to December 2016 were enrolled for epidemiological investigation. Smear, imaging, tuberculin test, clinical signs and anti-TBGL and anti-LAM antibody tests were used to diagnose the effective serum samples, and drug sensitivity tests were conducted to record the positive rate and drug resistance of the patients. Univariate and multivariate analyses were performed on all the factors influencing the recurrence of the patients including the gender, age, marriage, nutritional status, initial lesion range, regular treatment, drug withdrawal residual cavity, drug resistance, treatment style, course of treatment, and comorbidities. Results There were significant differences in epidemiological survey results in age, occupation and detection methods (P<0.05). A total of 22 703 strains were obtained in the drug sensitivity test, 19.99% of which were isoniazid resistance, 15.54% were streptomycin resistance, and 15.19% were multi-drug resistance.. In the process of antibody diagnosis, the positive rate of the parallel test was significantly higher than that of the single test and the series test, with a statistically significant difference (P<0.05). The results of risk factor analysis showed that age, drug withdrawal residual cavity, and drug resistance were important risk factors influencing the recurrence of the patients (P<0.05). Conclusion The incidence rate of tuberculosis in Baotou from 2012 to 2016 was affected by age, occupation and other factors. It is of great significance to develop diagnostic methods with higher sensitivity. The parallel detection of anti-TBGL and anti-LAM antibodies had high sensitivity and specificity, which is an important diagnostic method for tuberculosis with high application value. At the same time, the recurrence of tuberculosis is affected by many factors, which requires patients to be cooperative with treatment in order to improve the cure rate
