Preparation and in vitro release of tacrolimus-loaded cationic nanoemulsion-based in-situ gel
10.12206/j.issn.1006-0111.201911075
- VernacularTitle:他克莫司阳离子微乳原位凝胶的制备及体外释放研究
- Author:
Xin LIN
1
;
Jialiang ZHANG
2
;
Hongtao SONG
2
,
3
Author Information
1. Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350108, China.
2. Department of pharmacy, No. 900 Hospital of Joint Logistic Support Force of the PLA, Fuzhou 350025, China.
3. Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350108, China
- Keywords:
tacrolimus;
cationic nanoemulsion-based in-situ gel;
drug release in vitro
- From:
Journal of Pharmaceutical Practice
2020;38(4):307-311
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to improve the problems of poor water-solubility and low bioavailability of ocular tacrolimus, a cationic nanoemulsion in-situ gel of tacrolimus was developed and its drug release behavior in vitro was studied to provide a basis for further research. Methods Tacrolimus-loaded cationic nanoemulsion was prepared by high pressure homogenization and dispersed in poloxamer 407 and poloxamer 188 to prepare tacrolimus-loaded cationic nanoemulsion-based in-situ gel. The membraneless dissolution model was used to study the in vitro drug release behavior. Results The inverse glass bottle method was used to determine the gelation temperature. The optimal formulation of gel matrix was screened out as 26% poloxamer 407 and 12% poloxamer 188. The in vitro release results showed that the rate of gel dissolution determined the in vitro drug release. Conclusion Tacrolimus-loaded cationic nanoemulsion-based in-situ gel is successfully prepared. Its in vitro drug release is stable. It meets the requirement of ophthalmic formulation and shows good prospects for ocular application.
