Preparation and formulation optimization of wound dressings with nitrocellu-lose as membrane material
10.12206/j.issn.1006-0111.201910082
- VernacularTitle:以硝化纤维为膜材的伤口敷料的制备及处方优化
- Author:
Lingna ZHANG
1
;
Tianyu WANG
1
;
Wanfeng HONG
1
;
Chun TAO
1
;
Hongtao SONG
1
Author Information
1. No. 900 Hospital of Joint Logistic Support Forces of the PLA, Fuzhou 350025, China.
- Keywords:
wound dressing;
nitrocellulose;
, formulation optimization
- From:
Journal of Pharmaceutical Practice
2020;38(4):301-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare a wound dressing using nitrocellulose as a membrane and optimize its formulation. Methods Partial analysis was performed on commercial available products. The wound dressings were prepared by using nitrocellulose as a film-forming material, benzyl alcohol as a bacteriostatic agent, castor oil as a plasticizer, isopropyl palmitate as a skin emollient, camphor as a fragrance, and isopropyl alcohol, ethyl acetate and butyl acetate as volatile solvent. The tensile strength, breakpoint elongation percentage, breathability and waterproof performance were tested and evaluated. Results The film-forming performance of the prepared liquid wound dressing was good. The final use amount of nitrocellulose was determined to be 6%. The use amount of plasticizer castor oil was determined to be 4%. Conclusion The prepared liquid wound dressing has good film-forming property, good mechanical property, good waterproof and certain breathability.
