Role of Shear Wave Elastography in Evaluating the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B.
- Author:
Jae Yoon JEONG
1
;
Joo Hyun SOHN
;
Won SOHN
;
Chan Hyuk PARK
;
Tae Yeob KIM
;
Dae Won JUN
;
Yongsoo KIM
;
Woo Kyoung JEONG
Author Information
- Publication Type:Original Article
- Keywords: Elastography; shear wave; Liver stiffness; Hepatitis B; chronic; Carcinoma; hepatocellular
- MeSH: Carcinoma, Hepatocellular*; Elasticity Imaging Techniques*; Fibrosis; Follow-Up Studies; Hepatitis B; Hepatitis B, Chronic*; Hepatitis, Chronic*; Humans; Incidence; Liver; Male; Multivariate Analysis; Retrospective Studies
- From:Gut and Liver 2017;11(6):852-859
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: To investigate the use of measurements of liver stiffness (LS) by two-dimensional real-time shear wave elastography (SWE) for predicting the development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). METHODS: We retrospectively collected data on 291 enrolled patients with CHB whose LS had been measured using SWE. RESULTS: The mean age of the patients was 46.8 years; males predominated (67%), and 40 of the patients (14%) had clinical cirrhosis. Among the patients, 165 (56.7%) received antiviral treatment. The median LS value was 7.4 kPa, and the median follow-up period was 35.8 months (range, 3.0 to 52.8 months). During follow-up, HCC developed in 13 patients (4.5%), and the cumulative incidence rates of HCC at 1, 2, and 4 years were 1.1%, 3.6%, and 8.4%, respectively. Based on a multivariate analysis, older age (≥50 years) and higher LS value (≥10 kPa) were independently associated with the risk of developing HCC (hazard ratio [HR], 4.53, p=0.023; and HR, 4.08, p=0.022). The cumulative incidence rate of HCC was significantly higher in patients with higher LS values (≥10 kPa) than in those with lower LS values ( < 10 kPa) (p=0.001). CONCLUSIONS: Increased LS measured by SWE at any time point regardless of antiviral treatment is associated with an increased risk of HCC in patients with CHB.
