Relationship between circular RNA and type 2 diabetes and its clinical application
10.11665/j.issn.1000-5048.20200316
- VernacularTitle:环状RNA与2型糖尿病关系及其临床应用
- Author:
Jinming MU
1
;
Yue LIU
;
Fangfang ZHANG
;
Liang JIN
Author Information
1. 中国药科大学生命科学与技术学院
- Publication Type:Journal Article
- Keywords:
circular RNA;
islet beta cells;
type 2 diabetes;
biomarkers
- From:
Journal of China Pharmaceutical University
2020;51(3):374-378
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA (circRNA) is a novel type of non-coding RNA with covalently closed loops which plays an important role in the occurrence and development of type 2 diabetes. In this paper, the relationship between circRNA and type 2 diabetes in terms of the regulation of pancreatic β-cell function by circRNA and the metabolic activity of heart, kidney and other organs is reviewed, and the possibility of circRNA as a clinical diagnostic marker for type 2 diabetes and its complications is emphasized, hoping to provide reference and clues for the prevention, diagnosis and treatment of type 2 diabetes.
