Research progress of lncRNA regulating signal transduction pathway in liver diseases
10.11665/j.issn.1000-5048.20200304
- VernacularTitle:LncRNA调控肝脏疾病中信号转导通路的研究进展
- Author:
Li LIU
1
;
Qianwen ZHANG
;
Cheng NONG
;
Xi ZHANG
;
Xiaoting XU
Author Information
1. 中国药科大学江苏省新药筛选重点实验室
- Publication Type:Journal Article
- Keywords:
long non-coding RNA;
liver disease;
signal transduction pathway;
progress
- From:
Journal of China Pharmaceutical University
2020;51(3):277-286
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of liver disease is increasing year by year. Due to the complex predisposing factors and unclear pathogenesis of liver diseases, the cure rate is still not ideal, so it is urgent to clarify its mechanism to find more effective therapeutic targets and drugs. Long non-coding RNA (lncRNA), as a non-coding RNA with a length of more than 200 nt, is a research hotspot in liver diseases in recent years. Focusing on the main signal transduction pathways in liver diseases, this review mainly summarizes the latest research progress of lncRNA in regulating liver disease-related signaling pathways, and elaborates that lncRNAs participate in various physiological processes such as cell proliferation, apoptosis, invasion, and migration by regulating key signaling pathways in liver diseases, thereby promoting the occurrence and development of liver diseases. This review provides new ideas for studying the mechanism of liver diseases, and new directions for finding new targets and biomarkers for the treatment of liver diseases.
