Research progress on molecular markers related to the donor kidney injury from organ donation after citizen's death
10.3969/j.issn.1674-7445.2020.04.018
- VernacularTitle:公民逝世后器官捐献供肾损伤相关分子标志物的研究进展
- Author:
Fei HAN
1
;
Qiquan SUN
Author Information
1. Department of Renal Transplantation, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
- Publication Type:Research Article
- Keywords:
Renal transplantation;
Molecular marker;
Expanded criteria donor;
Mitochondrial DNA;
Serum cystatin C (Cys-C);
Neutrophil gelatinase-associated lipocalin (NGAL);
Liver-fatty acid-binding protein (L-FABP);
Kidney injury molecule-1 (KIM-1)
- From:
Organ Transplantation
2020;11(4):526-
- CountryChina
- Language:Chinese
-
Abstract:
Shortage of donor kidney is a major problem in renal transplantation. Accurate evaluation of donor kidney function may reduce the organ rejection rate and save more patients with uremia. Compared with pathological examination, detection of circulating molecular markers is more convenient in clinical application. In this article, the research progress on the markers of kidney injury, such as serum creatinine, serum cystatin C (Cys-C), neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), mitochondrial DNA (mtDNA), kidney injury molecule-1(KIM-1) and interleukin -18 (IL-18), were briefly reviewed.
