Klotho: a potential protective protein for renal graft
10.3969/j.issn.1674-7445.2020.04.015
- VernacularTitle:Klotho：一个潜在的移植肾保护蛋白
- Author:
Jinyang ZHUANG
1
;
Dong LIU
;
Gengguo DENG
;
Xiao WANG
Author Information
1. Guangdong Medical University, Zhanjiang 524002, China
- Publication Type:Research Article
- Keywords:
Klotho;
Renal transplantation;
Renal protective protein;
Aging;
Inflammation;
Oxidative stress;
Apoptosis;
Renal graft function
- From:
Organ Transplantation
2020;11(4):508-
- CountryChina
- Language:Chinese
-
Abstract:
Klotho gene is an anti-aging gene that is highly expressed in the kidney. Its encoding product Klotho protein can inhibit inflammation, oxidative stress injury, and apoptosis in renal tissue. It is regarded as a renal protective protein and expected to be a new target for the treatment of renal diseases. This article reviewed the biological characteristics of Klotho and the protective effect of Klotho on renal graft function.
