Research progress on human herpesvirus 6 infection after liver transplantation
10.3969/j.issn.1674-7445.2020.04.014
- VernacularTitle:肝移植术后人类疱疹病毒6型感染的研究进展
- Author:
Min LIU
1
;
Liying SUN
Author Information
1. Beijing Friendship Hospital, Capital Medical University, Clinical Diagnosis and Research Center of Pediatric Liver Transplantation of Capital Medical University, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
Liver transplantation;
Human herpesvirus 6;
Cytomegalovirus;
Hepatitis C virus;
Latent infection;
Immunosuppression;
Lymphocyte;
Opportunistic infection
- From:
Organ Transplantation
2020;11(4):502-
- CountryChina
- Language:Chinese
-
Abstract:
Human herpesvirus 6 (HHV-6) may establish lifetime latency after initial invasion of the host, and liver transplant recipients may experience reactivation of latent infection during immunosuppression. HHV-6 infection in liver transplant recipients could lead to fever, hepatitis, encephalitis and graft dysfunction, and indirectly increases the risk of progression of liver fibrosis due to cytomegalovirus (CMV), hepatitis C virus (HCV) infection. At present, the pathogenesis of HHV-6 infection after liver transplantation has not been systematically elucidated, and effective prevention and treatment strategies are still lacking. This article provided a review for the research progress on the pathogenesis, risk factors, diagnosis and treatment of HHV-6 infection after liver transplantation.
