Clinical efficacy analysis of pediatric blood type incompatible living donor liver transplantation
10.3969/j.issn.1674-7445.2020.04.007
- VernacularTitle:小儿血型不合活体肝移植的临床疗效分析
- Author:
Chao SUN
1
;
Xingchu MENG
;
Chong DONG
;
Kai WANG
;
Weiping ZHENG
;
Hong QIN
;
Chao HAN
;
Yang YANG
;
Fubo ZHANG
;
Shunqi CAO
;
Min XU
;
Wei GAO
Author Information
1. Organ Transplantation Center, Tianjin First Central Hospital, Tianjin Key Laboratory of Organ Transplantation, Tianjin 300192, China
- Publication Type:Research Article
- Keywords:
Blood type incompatible;
Pediatric recipient;
Liver transplantation;
Donor specific antibody;
Erythrocyte antibody;
Rejection;
Human leukocyte antigen
- From:
Organ Transplantation
2020;11(4):466-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of pediatric blood type incompatible living donor liver transplantation. Methods The clinical data from 242 cases of pediatric living donor liver transplantation recipients were retrospectively analyzed. Recipients were assigned to group A (ABO-identical group, n=165), group B (ABO-compatible group, n=42) and group C (ABO-incompatible group, n=35) according to the blood type compatibility between the recipients and the donors. The occurrence of postoperative complications and development of postoperative donor specific antibody (DSA) among the 3 groups were observed and compared. And the blood type distribution of donors and recipients and development of erythrocyte antibodies in group C were analyzed. The survival situation of recipients after liver transplantation was compared among the 3 groups. Results There was no significant difference in the incidence of complications among the 3 groups(all P > 0.05). DSA was dominated by human leukocyte antigen (HLA) Ⅱ antibodies after liver transplantation, mostly anti-HLA-DR and anti-HLA-DQ. The postoperative erythrocyte antibodies for liver transplant recipients in group C were dominated by IgM, with titers ≤1:2 for all. The differences in postoperative survival rates were not statistically significant among 3 groups(all P > 0.05). Conclusions Pediatric blood type incompatible living donor liver transplantation is a safe and effective treatment, which can effectively expand the source of liver transplant donors and save the children's lives.
